KEGG   REACTION: R04435
Entry
R04435                      Reaction                               
Name
phosphoenolpyruvate:N-acetyl-D-mannosamine-6-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming);
N-acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
Definition
N-Acetylneuraminate 9-phosphate + Orthophosphate <=> N-Acetyl-D-mannosamine 6-phosphate + Phosphoenolpyruvate + H2O
Equation
Comment
multi-step reaction
Reaction class
RC00159  C04257_C06241
Enzyme
2.5.1.56        2.5.1.57
Pathway
rn00520  Amino sugar and nucleotide sugar metabolism
rn01100  Metabolic pathways
rn01250  Biosynthesis of nucleotide sugars
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.56
     R04435  N-Acetylneuraminate 9-phosphate + Orthophosphate <=> N-Acetyl-D-mannosamine 6-phosphate + Phosphoenolpyruvate + H2O
    2.5.1.57
     R04435  N-Acetylneuraminate 9-phosphate + Orthophosphate <=> N-Acetyl-D-mannosamine 6-phosphate + Phosphoenolpyruvate + H2O
IUBMB reaction hierarchy [BR:br08202]
 2. Transferase reactions
  2.5.1.57
   R02769  N-Acylneuraminate 9-phosphate <=> N-Acyl-D-mannosamine 6-phosphate
    R04435  N-Acetylneuraminate 9-phosphate <=> N-Acetyl-D-mannosamine 6-phosphate
Orthology
K01654  N-acetylneuraminate synthase [EC:2.5.1.56]
K05304  sialic acid synthase [EC:2.5.1.56 2.5.1.57 2.5.1.132]

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